PET Pharmacokinetic Modeling
Our research is rooted in quantitative Positron Emission Tomography (PET) imaging methods that enable absolute quantification of in vivo processes such as cerebral blood flow, glucose metabolism, enzyme activity, protein expression, neurotransmitter system function (e.g., opiate, benzodiazepine, serotonin, dopamine) and neuropathological protein accumulation (e.g., amyloid-beta plaques, hyperphosphorylated tau tangles).
Our PET methodology research includes pharmacokinetic modeling, kinetic evaluation of novel PET radiotracers, study design, data analysis/interpretation and computer simulation studies.
Some of our active research areas are: neurodegeneration, diabetes, and simultaneous PET/MR imaging.
We actively participate in mentorship and research training activities for undergraduates, summer students, graduate students, fellows and faculty interested in PET and simultaneous PET/MR imaging (with Dr. Catana’s and Dr. Hooker’s research groups).
Our group is based at the Athinoula A. Martinos Center, part of the Massachussets General Hospital, and affiliated to the Harvard Medical School and the MGH Department of Radiology.
Latest from us
Dr. Shrestha talks at the Brainmap seminar
July 20, 2017
Stal Shrestha, PhD, from NIH, will give a Brainmap talk July 26 entitled ‘Novel PET radioligands show potential as a neuroinflammation biomarker and to monitor expression of designed receptors’
Dr. Mowrey talks at the Brainmap seminar
July 14, 2017
Wenzhu Mowrey, PhD, from Albert Einstein College of Medicine, will give a Brainmap talk on July 19th entitled ‘Sparse k-means clustering with resampling: A method developed to define amyloid-positivity among cognitively normal elderly’
Dr. Esterlis talks at the Brainmap seminar
March 11, 2017
Irina Esterlis, PhD, from Yale University, will give a talk at the Brainmap seminar next March 22nd at noon. The title of the talk is “Down with mGluR5, up with synaptic density: Insights from PET imaging studies”.
PET Pharmacokinetics Course In Dresden
December 10, 2016
The PET Pharmacokinetics Course will be held March 29th – 31st, 2017 in Dresden, Germany. The course will take place just prior to BRAIN & BRAIN PET 2017 (Berlin, Germany, April 1st – 4th, 2017).
Dr. Hassan Mohy-ud-Din talks on cardiac imaging
November 9, 2016
Hassan Mohy-ud-Din, PhD, a research fellow at Yale, will join us this Friday Nov. 11th. He will speak in the South Central conference room at 1:30pm about “Quantitative PET and SPECT: Applications in Cardiac Imaging”
Prof. Gunn talks at the Brainmap seminar
October 30, 2016
Prof. Roger Gunn will give a talk at the Brainmap seminar next Nov. 2nd at noon. The title of the talk is “Human Molecular Imaging as a Technique to Advance Disease Understanding and Drug Development”.