PET Pharmacokinetic Modeling

Our research is rooted in quantitative Positron Emission Tomography (PET) imaging methods that enable absolute quantification of in vivo processes such as cerebral blood flow, glucose metabolism, enzyme activity, protein expression, neurotransmitter system function (e.g., opiate, benzodiazepine, serotonin, dopamine) and neuropathological protein accumulation (e.g., amyloid-beta plaques, hyperphosphorylated tau tangles). 

Our PET methodology research includes pharmacokinetic modeling, kinetic evaluation of novel PET radiotracers, study design, data analysis/interpretation and computer simulation studies.

Some of our active research areas are: neurodegeneration, diabetes, and simultaneous PET/MR imaging.

We actively participate in mentorship and research training activities for undergraduates, summer students, graduate students, fellows and faculty interested in PET and simultaneous PET/MR imaging (with Dr. Catana’s and Dr. Hooker’s research groups).

Our group is based at the Athinoula A. Martinos Center, part of the Massachussets General Hospital, and affiliated to the Harvard Medical School and the MGH Department of Radiology.

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